KVA-D-88 is a potent phosphodiesterase 4 (PDE4) inhibitor, specifically targeting PDE4B and PDE4D with IC50 values of 140 nM and 880 nM, respectively. This compound readily crosses the blood-brain barrier and promotes cAMP accumulation, thereby modulating neuroactive substance-driven behaviors such as hyperlocomotion and locomotor sensitization. KVA-D-88 is valuable for research applications focused on drug addiction and related neurobiological processes.
KVA-D-88 is a potent phosphodiesterase 4 (PDE4) inhibitor, specifically targeting PDE4B and PDE4D with IC50 values of 140 nM and 880 nM, respectively. This compound readily crosses the blood-brain barrier and promotes cAMP accumulation, thereby modulating neuroactive substance-driven behaviors such as hyperlocomotion and locomotor sensitization. KVA-D-88 is valuable for research applications focused on drug addiction and related neurobiological processes.
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