KW-2449

Catalog No.: A10508

FLT3/FGFR/Bcr-Abl/Aurora Inhibitor

KW-2449 Chemical Structure

CAS NO. 1000669-72-6

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.

Availability: In stock

Package Price Qty
10 mg
$50.00
50 mg
$220.00
100 mg
$400.00
200 mg
$680.00
10mM * 1mL in DMSO
$76.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
Targets
Target Value
FLT3(D835Y)IC50: 1nM
Abl(T315I)IC50: 4nM
FLT3IC50: 6.6nM
AblIC50: 14nM
FGFR1IC50: 36nM
AuroraAIC50: 48nM
JAK2IC50: 150nM
KitIC50: 300nM
SrcIC50: 400nM
PDGFRαIC50: 1.7μM
In vitro (25°C) DMSO 67 mg/mL (201.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol 67 mg/mL (201.56 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.08 mL 150.42 mL 300.84 mL
0.5 mM 6.02 mL 30.08 mL 60.17 mL
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL

*The above data is based on the productmolecular weight 332.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10508
Actions Inhibitor
M. Wt 332.4
Formula

C20H20N4O

Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1000669-72-6
Synonyms KW 2449, KW2449
SMILES C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43

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