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FLT3/FGFR/Bcr-Abl/Aurora Inhibitor

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Catalog No. A10508

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
KW-2449 10mg A10508-10

Regular Price: $50.00

Special Price: $45.00

KW-2449 50mg A10508-50

Regular Price: $220.00

Special Price: $198.00

KW-2449 100mg A10508-100

Regular Price: $400.00

Special Price: $360.00

KW-2449 200mg A10508-200

Regular Price: $680.00

Special Price: $612.00

KW-2449 10mM * 1mL in DMSO A10508-10mM-D

Regular Price: $76.00

Special Price: $68.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.


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Chemical Information

Catalog Num A10508
Actions Inhibitor
M. Wt 332.4


Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1000669-72-6
Synonyms KW 2449, KW2449

Biological Activity

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
Target Value
FLT3(D835Y)IC50: 1nM
Abl(T315I)IC50: 4nM
FLT3IC50: 6.6nM
AblIC50: 14nM
FGFR1IC50: 36nM
AuroraAIC50: 48nM
JAK2IC50: 150nM
KitIC50: 300nM
SrcIC50: 400nM
PDGFRαIC50: 1.7μM


Solubility (25°C) * In vitro DMSO 67 mg/mL (201.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol 67 mg/mL (201.56 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.08 mL 150.42 mL 300.84mL
0.5 mM 6.02 mL 30.08 mL 60.17 mL
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL

*The above data is based on the productmolecular weight 332.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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