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Catalog No.: A10508

FLT3/FGFR/Bcr-Abl/Aurora Inhibitor


KW-2449 Chemical Structure

CAS NO. 1000669-72-6

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.

Availability: In stock

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10 mg
50 mg
100 mg
200 mg
10mM * 1mL in DMSO
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Biological Activity

KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
Target Value
FLT3(D835Y)IC50: 1nM
Abl(T315I)IC50: 4nM
FLT3IC50: 6.6nM
AblIC50: 14nM
FGFR1IC50: 36nM
AuroraAIC50: 48nM
JAK2IC50: 150nM
KitIC50: 300nM
SrcIC50: 400nM
PDGFRαIC50: 1.7μM
In vitro (25°C) DMSO 58 mg/mL (174.48 mM)
Water Insoluble
Ethanol 58 mg/mL (174.48 mM)
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.08 mL 150.42 mL 300.84 mL
0.5 mM 6.02 mL 30.08 mL 60.17 mL
1 mM 3.01 mL 15.04 mL 30.08 mL
5 mM 0.6 mL 3.01 mL 6.02 mL

*The above data is based on the productmolecular weight 332.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10508
Actions Inhibitor
CAS No. 1000669-72-6
Formula C20H20N4O
M. Wt 332.4
Purity >98%
Synonyms KW 2449, KW2449

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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