L-368,899 is a selective antagonist of the oxytocin (OT) receptor, exhibiting IC50 values of 8.9 nM and 26 nM in rat and human uterine tissues, respectively. This orally active compound effectively crosses the blood-brain barrier and is proven to inhibit oxytocin-stimulated uterine contractions in rat models. L-368,899 is valuable for research into preterm labor and the physiological roles of oxytocin in reproductive biology.
L-368,899 is a selective antagonist of the oxytocin (OT) receptor, exhibiting IC50 values of 8.9 nM and 26 nM in rat and human uterine tissues, respectively. This orally active compound effectively crosses the blood-brain barrier and is proven to inhibit oxytocin-stimulated uterine contractions in rat models. L-368,899 is valuable for research into preterm labor and the physiological roles of oxytocin in reproductive biology.
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