L-372662 is a potent, orally active non-peptide antagonist of the oxytocin receptor (OTR). It has a Ki value of 4.8 nM and demonstrates high affinity with Kd values of 5.8 nM for wild-type OTR and 73 nM for the [A318G] variant. This compound exhibits selectivity for OTR over the vasopressin 1a receptor (V1aR), making it a valuable tool in research applications related to neuroendocrine regulation and social behavior.
L-372662 is a potent, orally active non-peptide antagonist of the oxytocin receptor (OTR). It has a Ki value of 4.8 nM and demonstrates high affinity with Kd values of 5.8 nM for wild-type OTR and 73 nM for the [A318G] variant. This compound exhibits selectivity for OTR over the vasopressin 1a receptor (V1aR), making it a valuable tool in research applications related to neuroendocrine regulation and social behavior.
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