L-771688 hydrochloride is a highly potent and selective α1A-adrenoceptor antagonist, exhibiting a Kd of 43-90 pM. It demonstrates strong affinity for cloned human, rat, and canine α1A-adrenergic receptors, with a Ki of less than 1 nM and over 500-fold selectivity against the α1B and α1D isoforms. L-771688 effectively blocks norepinephrine-induced responses, making it useful for studying adrenergic signaling pathways. Its ability to inhibit contractions induced by phenylephrine or A-61603 in various animal models further underscores its applications in cardiovascular research.
L-771688 hydrochloride is a highly potent and selective α1A-adrenoceptor antagonist, exhibiting a Kd of 43-90 pM. It demonstrates strong affinity for cloned human, rat, and canine α1A-adrenergic receptors, with a Ki of less than 1 nM and over 500-fold selectivity against the α1B and α1D isoforms. L-771688 effectively blocks norepinephrine-induced responses, making it useful for studying adrenergic signaling pathways. Its ability to inhibit contractions induced by phenylephrine or A-61603 in various animal models further underscores its applications in cardiovascular research.
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