Fig. 1 · Structure
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L-Azidohomoalanine hydrochloride
PROTAC Linkers
L-Azidohomoalanine hydrochloride is a versatile PROTAC linker featuring an azide functional group, facilitating the synthesis of protein-targeting chimeras. This compound demonstrates key click chemistry capabilities, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN groups, making it invaluable for bioconjugation and drug discovery applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 942518-29-8 |
| Applications | PROTAC Linkers |
| Formula | C4H9ClN4O2 |
| Molecular Weight | 180.59 |
| SMILES | O=C(O)[C@@H](N)CCN=[N+]=[N-].[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.