L-Azidohomoalanine hydrochloride is a versatile PROTAC linker featuring an azide functional group, facilitating the synthesis of protein-targeting chimeras. This compound demonstrates key click chemistry capabilities, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN groups, making it invaluable for bioconjugation and drug discovery applications.
L-Azidohomoalanine hydrochloride is a versatile PROTAC linker featuring an azide functional group, facilitating the synthesis of protein-targeting chimeras. This compound demonstrates key click chemistry capabilities, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions when paired with DBCO or BCN groups, making it invaluable for bioconjugation and drug discovery applications.
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