Lactandrate targets the estrogen receptor alpha (ERα) as a D-high nitrogen steroid alkylating agent. It exhibits a significant growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. In vivo studies have demonstrated its anti-tumor activity in mouse models of breast cancer, including MXT and CD8F1 strain tumors, as well as in human xenograft MX-1 models. Lactandrate serves as a valuable reagent for research in cancer biology, particularly in studying estrogen receptor modulation and breast cancer therapeutics.
Lactandrate targets the estrogen receptor alpha (ERα) as a D-high nitrogen steroid alkylating agent. It exhibits a significant growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. In vivo studies have demonstrated its anti-tumor activity in mouse models of breast cancer, including MXT and CD8F1 strain tumors, as well as in human xenograft MX-1 models. Lactandrate serves as a valuable reagent for research in cancer biology, particularly in studying estrogen receptor modulation and breast cancer therapeutics.
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