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Biological Activity
Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
Targets
| Sodium channel | 5-HT (human platelets) | 5-HT (rat brain synaptosomes) | ||
| N/A | 240 μM | 474 μM |
| In vitro (25°C) | DMSO | 9 mg/mL (35.14 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (11.71 mM) | ||
| In vivo | 0.5% methylcellulose | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 39.05 mL | 195.24 mL | 390.49 mL |
| 0.5 mM | 7.81 mL | 39.05 mL | 78.1 mL |
| 1 mM | 3.9 mL | 19.52 mL | 39.05 mL |
| 5 mM | 0.78 mL | 3.9 mL | 7.81 mL |
*The above data is based on the productmolecular weight 256.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11873 |
|---|---|
| CAS No. | 84057-84-1 |
| Formula | C9H7Cl2N5 |
| M. Wt | 256.09 |
| Purity | >98% |
| SMILES | C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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