2018-2019 AdooQ Catalog Book Available Click here to download

World Leading Inhibitor Supplier

United States
  • Toll Free 866-930-6790
Trusted by 10,000+ Scientists since 2006

Lapatinib (free base)

ON SALE

0 Customer Reviews
Catalog No. A11752

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Lapatinib 10mg A11752-10

Regular Price: $30.00

Special Price: $27.00

Lapatinib 25mg A11752-25

Regular Price: $40.00

Special Price: $36.00

Lapatinib 50mg A11752-50

Regular Price: $50.00

Special Price: $45.00

Lapatinib 100mg A11752-100

Regular Price: $70.00

Special Price: $63.00

Lapatinib (free base) 10mM * 1mL in DMSO A11752-10mM-D

Regular Price: $50.00

Special Price: $45.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.

Lapatinib (free base)

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products
Lapatinib (free base) Citations (4)
  • Tzeng SF,et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 29906246
  • Fujita KI,et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 28479358
  • Yuki Kawasaki,et al. Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain, Sci Rep, 2016, 6: 31502 27531070
  • Tetsuya Saita,et al. Preparation of Antibodies and Development of an Enzyme-Linked Immunosorbent Assay for the Tyrosine Kinase Inhibitors Lapatinib and Nilotinib., Biol Pharm Bull. , 2015, 38(10):1652-7 26424026

Chemical Information

Catalog Num A11752
Actions N/A
M. Wt 581.1
Formula C29H26ClFN4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 231277-92-2
Synonyms N/A
SMILES code CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl
Chemical Name N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate

Biological Activity

Description
 Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
Targets
Target Value
ErbB2IC50: 9.2nM
EGFRIC50: 10.8nM
ErbB4IC50: 367nM
c-SrcIC50: 3.5μM
C-Raf-1IC50: >10μM
MEKIC50: >10μM
ERKIC50: >10μM
c-FmsIC50: >10μM
CDK1IC50: >10μM
CDK2IC50: >10μM
p38IC50: >10μM
Tie-2IC50: >10μM
VEGFR2IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (172.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.21 mL 86.04 mL 172.09mL
0.5 mM 3.44 mL 17.21 mL 34.42 mL
1 mM 1.72 mL 8.6 mL 17.21 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Be the first to review this product

Similar product(s)


Keywords:buy Lapatinib (free base) | Lapatinib (free base) Supplier | purchase Lapatinib (free base) | Lapatinib (free base) cost | Lapatinib (free base) manufacturer | order Lapatinib (free base) | Lapatinib (free base) distributor | buy 231277-92-2| 231277-92-2 Supplier | purchase 231277-92-2 | 231277-92-2 cost | 231277-92-2 manufacturer | order 231277-92-2 | 231277-92-2 distributor

Receive our newsletter

To keep up to date with the latest products, news from us. We only send a few emails a year and you can unsubscribe at any time.

We Using Safe Payments:
© 2006-2018 AdooQ BioScience. All Rights Reserved.