Lapatinib (free base)

Catalog No.: A11752

Lapatinib (free base) Chemical Structure

CAS NO. 231277-92-2

Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.

Availability: In stock

Package Price Qty
10 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO

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Biological Activity

Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway.
Target Value
ErbB2IC50: 9.2nM
EGFRIC50: 10.8nM
ErbB4IC50: 367nM
c-SrcIC50: 3.5μM
C-Raf-1IC50: >10μM
MEKIC50: >10μM
ERKIC50: >10μM
c-FmsIC50: >10μM
CDK1IC50: >10μM
CDK2IC50: >10μM
p38IC50: >10μM
Tie-2IC50: >10μM
VEGFR2IC50: >10μM
In vitro (25°C) DMSO 100 mg/mL (172.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.21 mL 86.04 mL 172.09 mL
0.5 mM 3.44 mL 17.21 mL 34.42 mL
1 mM 1.72 mL 8.6 mL 17.21 mL
5 mM 0.34 mL 1.72 mL 3.44 mL

*The above data is based on the productmolecular weight 581.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11752
M. Wt 581.1
Formula C29H26ClFN4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 231277-92-2

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