Lazabemide hydrochloride is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.03 μM, demonstrating minimal activity against MAO-A (IC50 > 100 μM). At elevated concentrations, it inhibits monoamine uptake, with IC50 values of 86 μM for noradrenaline, 123 μM for serotonin, and >500 μM for dopamine. This compound is primarily used in research related to Parkinson's and Alzheimer's diseases, offering insights into the management of neurodegenerative disorders.
Lazabemide hydrochloride is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.03 μM, demonstrating minimal activity against MAO-A (IC50 > 100 μM). At elevated concentrations, it inhibits monoamine uptake, with IC50 values of 86 μM for noradrenaline, 123 μM for serotonin, and >500 μM for dopamine. This compound is primarily used in research related to Parkinson's and Alzheimer's diseases, offering insights into the management of neurodegenerative disorders.
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