LEB-03-145 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that effectively links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a C5 alkyl linker. This compound enhances the stability and activity of AZD1775 by modulating ubiquitination processes. LEB-03-145 is valuable for studying WEE1 regulation and offers potential in cancer research, particularly in the context of targeting tumor cell proliferation and survival pathways.
LEB-03-145 is a WEE1 deubiquitinase-targeting chimera (DUBTAC) that effectively links AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 via a C5 alkyl linker. This compound enhances the stability and activity of AZD1775 by modulating ubiquitination processes. LEB-03-145 is valuable for studying WEE1 regulation and offers potential in cancer research, particularly in the context of targeting tumor cell proliferation and survival pathways.
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