Lenalidomide 4'-alkyl-C3-azide is a click chemical reagent that incorporates an azide group into lenalidomide, facilitating the synthesis of PROTACs. As an orally active immunomodulator, lenalidomide acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN). This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling versatile modifications in chemical biology research.
Lenalidomide 4'-alkyl-C3-azide is a click chemical reagent that incorporates an azide group into lenalidomide, facilitating the synthesis of PROTACs. As an orally active immunomodulator, lenalidomide acts as a ligand for the ubiquitin E3 ligase cereblon (CRBN). This compound is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling versatile modifications in chemical biology research.
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