Lenalidomide-acetylene-Br serves as a PROTAC linker, integral to the design of HJM-561, which is a selective and orally bioavailable inhibitor targeting EGFR. This compound effectively addresses Osimertinib-resistant EGFR triple mutations, making it a valuable tool for research into cancer therapies that overcome resistance mechanisms. Its application in PROTAC-mediated protein degradation offers potential for advancing targeted therapeutic strategies in oncology.
Lenalidomide-acetylene-Br serves as a PROTAC linker, integral to the design of HJM-561, which is a selective and orally bioavailable inhibitor targeting EGFR. This compound effectively addresses Osimertinib-resistant EGFR triple mutations, making it a valuable tool for research into cancer therapies that overcome resistance mechanisms. Its application in PROTAC-mediated protein degradation offers potential for advancing targeted therapeutic strategies in oncology.
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