Lesogaberan napadisylate is a potent and selective agonist of the GABAB receptor, exhibiting an EC50 of 8.6 nM for human recombinant receptors. It demonstrates strong affinity for rat GABAB and GABAA receptors, with Kis values of 5.1 nM and 1.4 μM, respectively. This compound effectively inhibits transient lower esophageal sphincter relaxation, making it relevant for research into gastrointestinal disorders and neuromodulation.
Lesogaberan napadisylate is a potent and selective agonist of the GABAB receptor, exhibiting an EC50 of 8.6 nM for human recombinant receptors. It demonstrates strong affinity for rat GABAB and GABAA receptors, with Kis values of 5.1 nM and 1.4 μM, respectively. This compound effectively inhibits transient lower esophageal sphincter relaxation, making it relevant for research into gastrointestinal disorders and neuromodulation.
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