Lifirafenib (BGB-283)

Catalog No.: A16844

BRAF inhibitor

Lifirafenib (BGB-283)

Lifirafenib (BGB-283) Chemical Structure

CAS NO. 1446090-79-4

Lifirafenib (BGB-283), also known as Beigene-283, potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
50 mg
$480.00
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Biological Activity

Lifirafenib (BGB-283), also known as Beigene-283, potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.
In vitro DMSO 86 mg/mL (179.76 mM)
Water Insoluble
Ethanol 86 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.9 mL 104.51 mL 209.02 mL
0.5 mM 4.18 mL 20.9 mL 41.8 mL
1 mM 2.09 mL 10.45 mL 20.9 mL
5 mM 0.42 mL 2.09 mL 4.18 mL

*The above data is based on the productmolecular weight 478.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16844
Actions Inhibitor
CAS No. 1446090-79-4
Formula C25H17F3N4O3
M. Wt 478.42
Purity >98%
Synonyms BGB283, Beigene-283, BGB 283, Beigene283
SMILES O=C1NC2=NC=CC(OC3=CC=C(O[[email protected]@]4([H])[[email protected]]5([H])[[email protected]@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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