Linagliptin (BI-1356)

Catalog No.: A11224

DPP-4 Inhibitor

Linagliptin (BI-1356)

Linagliptin (BI-1356) Chemical Structure

CAS NO. 668270-12-0

Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

Availability: In stock

Package Price Qty
100 mg
$54.00
500 mg
$162.00
10mM * 1mL in DMSO
$50.00
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Biological Activity

Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
Targets
DPP-4
1 nM
In vitro (25°C) DMSO 16 mg/mL (33.85 mM)
Water Insoluble
Ethanol 1 mg/mL (2.11 mM)
In vivo 0.5% hydroxyethyl cellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.16 mL 105.82 mL 211.64 mL
0.5 mM 4.23 mL 21.16 mL 42.33 mL
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL

*The above data is based on the productmolecular weight 472.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11224
Actions Inhibitor
CAS No. 668270-12-0
Formula C25H28N8O2
M. Wt 472.5
Solubility DMSO
Purity >98%
Synonyms BI-1356,Tradjenta,Trajenta
SMILES CC#CCN1C2=C(N=C1N3CCC[[email protected]](C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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