Liposome

C13-112-tetra-tail is a cationic lipid-like compound characterized by a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. This compound is designed for the formulation of lipid nanoparticles (LNPs), making it suitable for various applications in drug delivery and gene therapy. Its unique structure facilitates enhanced cellular uptake and promotes the effective encapsulation of therapeutic agents.

PMPC is a phosphatidylcholine that features an asymmetric fatty acid configuration, with palmitic acid at the sn-1 position and myristic acid at the sn-2 position. This unique structure allows PMPC to play a critical role in the formation and stabilization of liposomes. It is widely utilized in drug delivery research, membrane studies, and formulations requiring targeted lipid-based carriers.

18:1 Biotinyl PE is a biotin-conjugated phosphoethanolamine lipid, featuring two oleic acid chains. This compound is designed for incorporation into liposomes, facilitating the targeting and tracking of liposomal formulations in various biological studies. It is valuable for applications such as drug delivery systems, cellular labeling, and biomolecular imaging research.

Octadecanedioic acid mono-L-carnitine ester is a cationic lipid that facilitates the formation of lipid nanoparticles (LNPs) by enhancing encapsulation efficiency. Its terminal carboxylic acid is reactive toward primary amine groups, enabling the formation of stable amide bonds in the presence of coupling agents such as HATU. This compound is valuable in various research applications including gene delivery, vaccine development, and targeted drug delivery systems.

Dielaidoylphosphatidylethanolamine is a phospholipid primarily utilized in the formation of liposomes. It serves as a vehicle for the targeted delivery of therapeutic agents, enhancing bioavailability and stability. This compound is particularly valuable in drug delivery studies and in the development of nanocarrier systems for both pharmaceutical and biomedical applications.

DMT7 is an ionizable cationic lipid with a pKa of 6.5, primarily utilized for the formulation of lipid nanoparticles (LNPs). Its ability to encapsulate mRNA and anticancer drugs makes it a valuable reagent in RNA-based therapeutics and cancer treatment research. DMT7 facilitates efficient delivery mechanisms, enhancing the bioavailability of nucleic acids and hydrophilic therapeutics in various biological applications.

16:0 MPB PE is a maleimide-functionalized lipid that targets thiol groups through its phenyl maleimide moiety, facilitating covalent conjugation. This phosphoethanolamine-based compound features two palmitic acid tails, making it suitable for the formation of liposomes. Its unique chemical properties enable applications in drug delivery systems and the development of targeted therapeutics. Researchers can utilize 16:0 MPB PE to explore various biochemical interactions and enhance the stability of lipid-based formulations.

Amino-Gly-Gly-DSPE hydrochloride is a modified phospholipid designed for liposome synthesis. Its terminal amine exhibits reactivity with NHS esters or carboxylic acids when combined with activation agents like HATU or EDC. This compound is fundamental in preparing functionalized liposomes for various biological applications, including drug delivery and membrane protein studies.

DSPE-PEG2000-Maleimide free acid is a phospholipid-PEG conjugate designed for targeted liposome and nanoparticle applications. This compound exploits the amphiphilic properties of DSPE to integrate into lipid bilayers, enabling effective delivery systems. Through thiol-maleimide click chemistry, it allows for the covalent attachment of ligands, such as antibodies, peptides, or proteins, facilitating targeted therapy. DSPE-PEG2000-Maleimide free acid is particularly valuable in research concerning breast cancer, lymphoma, and inherited retinal degeneration.

18:1 PE MCC is a maleimide-functionalized phosphoethanolamine lipid that features two oleic acid tails. Its thiol-reactive properties make it an effective tool for the preparation of liposomes and the development of targeted drug delivery systems. This compound is particularly useful in bioconjugation applications, facilitating the attachment of biomolecules to lipid surfaces for enhanced therapeutic efficacy.

1-Myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine (MPPC) is an asymmetric phosphatidylcholine that features myristic acid at the sn-1 position and palmitic acid at the sn-2 position. This compound is primarily utilized in the formation of liposomes and micelles, serving as a critical component in the development of artificial membranes. Due to its unique structure, MPPC plays a significant role in membrane fusion studies and drug delivery applications.

18:1 Caproylamine PE is an amine-functionalized phospholipid that features a phosphoethanolamine headgroup linked to two oleic acid fatty acid tails. This compound serves as a critical building block in the formulation of liposomes, enhancing their stability and encapsulation efficiency. Due to its unique properties, it is widely utilized in drug delivery systems and membrane structure studies, facilitating investigations in pharmaceutical and biotechnological research applications.

1,2-PLPC is a phospholipid structured with palmitoyl (16:0) at the sn-1 position and lauryl (12:0) at the sn-2 position, targeting liposome formation. This reagent is effective in the generation of micelles and artificial membranes, making it valuable for studies involving lipid bilayers and membrane dynamics. Its unique configuration facilitates the development of lipid-based delivery systems for drug transport and biophysical research applications.

mPEG-DMPE (MW 2000) is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine, featuring a methyl group at the terminus of the PEG chain. This amphiphilic compound facilitates the formation of stable micelles in aqueous environments, making it ideal for the preparation of nanoparticles or liposomes. Its primary applications include targeted drug delivery and enhancing bioavailability of therapeutics in various biomedical research settings.

23:2 Diyne PE (DC(8,9)PE) is a phospholipid featuring a hydrolyzed phosphocholine moiety and lipid tails composed of palmitic acid (16:0) and pentacosa-10,12-diynoic acid. This compound serves as a versatile building block for liposome formulation, enabling the development of advanced drug delivery systems. Its unique structure facilitates the incorporation of bioactive molecules, making it valuable for research in drug formulation and nanomedicine applications.

1,2-Didecanoyl-sn-glycero-3-phosphoethanolamine is a phospholipid that serves as an essential component for liposome formation. It exhibits significant potential as a P-glycoprotein (P-gp) inhibitor, demonstrating effective inhibitory activity at a concentration of 0.3 mM. This compound is valuable for research applications involving drug delivery systems and the study of multidrug resistance mechanisms in cancer pharmacology.

1,2-Dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol-5'-phosphate) ammonium is a membrane-bound signaling molecule that plays a critical role in regulating membrane trafficking and signal transduction. This compound is instrumental in the formulation of liposomes, thereby enhancing the efficacy of drug delivery systems. Additionally, it can coordinate the actin cytoskeleton, influencing cell morphology and motility, making it a valuable tool for research in cell biology and membrane dynamics.

DSPE-Pyrene is a phospholipid conjugate featuring a polycyclic aromatic hydrocarbon moiety. This reagent is primarily utilized for drug encapsulation applications, facilitating the formation of drug-loaded liposomes and nanoparticles. The pyrene component acts as a fluorescent probe, with its emission spectrum exhibiting sensitivity to environmental polarity, making it valuable for studying lipid bilayer dynamics and interactions in biological systems.

16:0 Cyanur PE is a cyanur-functionalized phosphoethanolamine lipid that incorporates two palmitic acid chains. This compound serves as a critical component in the formation of liposomes, enhancing their stability and versatility. The unique structural features of 16:0 Cyanur PE enable its application in drug delivery systems and nanocarrier design, facilitating targeted therapies and improving the bioavailability of therapeutic agents.

Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) designed for the formation of supramolecular lipid nanoparticles (SMLNPs), facilitating mRNA delivery. Research demonstrates its ability to effectively deliver encapsulated genetic materials, such as luciferase reporter genes, which accumulate in lymph nodes, indicating robust entry into the immune system. Additionally, Lipid N2-3L has shown potential in cancer therapy, evidenced by its capacity to reduce tumor volume and enhance survival in an MC-38-OVA mouse colon cancer model when used alongside ovalbumin mRNA and the TLR7/8 agonist Resiquimod. This lipid is a valuable tool for advancing research in targeted drug delivery for cancer therapies.

16:0 Glutaryl PE is a carboxylic acid-functionalized lipid designed for liposome formulation, featuring a three-carbon linker connected to a phosphoethanolamine moiety and two palmitic acid tails. This compound enhances the stability and biocompatibility of liposomal structures, making it suitable for drug delivery and gene therapy applications. The incorporation of 16:0 Glutaryl PE can facilitate the encapsulation of hydrophilic and hydrophobic compounds, thereby expanding its utility in various biopharmaceutical research contexts.

16:0 PE MCC is a maleimide-functionalized thiol-reactive lipid designed for liposome formulation. This compound features a phosphoethanolamine moiety connected to two palmitic acid tails, allowing for efficient conjugation with thiol-containing biomolecules. It is primarily utilized in the development of targeted drug delivery systems and bioconjugation applications in chemical and biological research.

18:1 Succinyl PE is a carboxylic acid-functionalized lipid targeting liposome formulation. Its structure features a two-carbon linker connected to phosphoethanolamine and two oleic acid tails, enabling effective incorporation into lipid membranes. This reagent is primarily utilized in studies involving drug delivery systems and the development of nanocarriers for therapeutic applications.

1,2-Dilinoleoyl-sn-glycero-3-phospho-L-serine sodium (18:2 PS sodium) is a phospholipid compound targeting liposome formation. It plays a crucial role in the construction of vesicles composed of concentric phospholipid bilayer membranes, serving as effective platforms for drug delivery systems, particularly in oncological and antimicrobial applications. This compound facilitates the encapsulation of highly polar water-soluble agents within the internal aqueous space of liposomes, while lipophilic compounds integrate into the lipid bilayer. Its use is especially advantageous for the delivery of antisense oligonucleotides, addressing challenges related to cellular uptake efficiency and systemic stability.

DMA4-H228 is a novel ionizable cationic liposome designed for targeted delivery to the spleen. This compound is utilized to formulate lipid nanoparticles (LNPs) that encapsulate mRNA, facilitating effective in vivo mRNA delivery for various therapeutic applications. Its unique properties make it a valuable tool in RNA-based research and gene delivery studies.

Heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate is a specialized lipid compound utilized in the formation of liposomes. Its structural properties allow for effective encapsulation of hydrophilic drugs, enhancing their bioavailability and delivery efficiency. This reagent is essential for research in drug delivery systems and formulation development, facilitating studies in pharmacokinetics and therapeutic efficacy.

16:0-23:2 Diyne PC is a phospholipid that contains palmitic acid (16:0) and pentacosa-10,12-diynoic acid in its acyl chains. This compound is primarily utilized in the formation of liposomes, serving as a crucial component for encapsulating bioactive molecules. Its unique structure and properties make it suitable for various biological applications, including drug delivery systems and membrane studies.

C16-18:1 PE is a phospholipid that facilitates membrane fusion and enhances endosomal escape, thereby significantly improving the delivery efficiency of mRNA. This compound is instrumental in the synthesis of lipid nanoparticles (LNP), making it valuable for applications in gene delivery and targeted therapeutics. Its ability to promote efficient cellular uptake of nucleic acids positions C16-18:1 PE as a key reagent in the development of mRNA-based therapies.

50-C2-C9-4tail is a lipid-based reagent designed for use in the formulation of lipid nanoparticles (LNPs), with a primary mechanism of enhancing siRNA and mRNA delivery. It exhibits significant efficacy in both in vitro and in vivo applications, facilitating the transport of nucleic acids for gene expression studies and therapeutic interventions. This compound is essential for researchers exploring RNA-based therapies and the optimization of LNP formulations.

(S)-O12-D3-I3 is an ionizable cationic lipid with a pKa of 6.39. It is primarily utilized for the formulation of lipid nanoparticles (LNPs), facilitating effective siRNA delivery for both in vitro and in vivo applications. This compound is particularly valuable in cancer research, including studies focused on liver and breast cancer, where targeted gene silencing is essential for therapeutic investigations.

C13-113-tri-tail is a cationic lipid-like compound characterized by a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. This compound facilitates the formation of lipid nanoparticles (LNP), enhancing gene delivery and the encapsulation of nucleic acids. Its design optimizes membrane fusion and cellular uptake, making it a valuable reagent for research in nucleic acid delivery systems and gene therapy applications.

tert-Butyl 3-(7-((undecan-3-yloxy)carbonyl)heptylamino)propylcarbamate is an aminolipid designed for liposome formulation. This compound features a Boc-protected primary amine along with a propylamine spacer connected to an octanoate chain, complemented by an undecyl side chain. Its unique structure facilitates the incorporation of hydrophobic drugs into lipid-based delivery systems, enhancing cellular uptake and therapeutic efficacy in various biomedical research applications.

Murapalmitine is a key component in the formulation of liposomes used for drug delivery applications. This molecule enhances the stability and bioavailability of encapsulated drugs, facilitating targeted delivery to specific tissues. Its utilization in liposomal systems supports various biomedical research areas, including cancer therapy, gene delivery, and vaccine formulation.

HAPC-Chol is a cationic cholesterol derivative that serves as a crucial component in the formation of lipoplexes. Its primary mechanism involves enhancing the stability and delivery efficiency of nucleic acids in gene therapy applications. HAPC-Chol promotes effective cellular uptake and release of therapeutic agents, making it an essential reagent in lipid-based transfection strategies and other biomedical research applications.

DLPS is an anionic phospholipid characterized by lauric acid (12:0) tails and a head group featuring both carboxylic acid (COOH) and amine (NH2) functionalities. It plays a crucial role in the formation of lipid-mixing vesicles and liposomes, serving as a key component in artificial membranes. The medium chain length of the fatty acid facilitates the production of thinner membrane structures, making DLPS an essential reagent for studies in membrane biology and drug delivery applications.

Bis(2-butyloctyl) 10-oxononadecanedioate is an ionizable lipid compound characterized by four hydrophobic tails linked via ester bonds. This compound plays a crucial role in the formation of liposomes, facilitating efficient encapsulation and delivery of mRNA. Its unique structure enhances biocompatibility and enhances payload stability, making it a valuable tool for research in gene therapy and vaccine development.

Cis-AY 9944 is a cholesterol synthesis inhibitor that specifically targets liposomal pathways. It demonstrates anticonvulsant activity by modulating the dynamics of spike-and-wave discharges observed in electroencephalogram (EEG) recordings. This compound is valuable for research into epilepsy mechanisms and metabolic processes involving cholesterol regulation.

16:0 Caproylamine PE is an amide-functionalized lipid featuring a phosphoethanolamine structure attached to two palmitic acid tails. This compound serves as a key component in the formation of liposomes, enabling the encapsulation and delivery of therapeutic agents. Its unique properties make it suitable for various applications in drug delivery systems and membrane studies, facilitating advancements in nanomedicine and biomedical research.

18:1 Ethylene Glycol is a liposome-forming reagent that facilitates the encapsulation and delivery of biological agents. It is particularly useful in drug delivery systems and vaccine development, enhancing the bioavailability and stability of therapeutics. This compound plays a critical role in the formulation of lipid-based nanocarriers for targeted therapy and cellular uptake studies.

DMPAC-Chol is a lipid used in the formulation of liposomes. This compound enhances the efficiency of transfection, making it suitable for various research applications, particularly in gene delivery and therapeutic development. Its unique properties facilitate improved cellular uptake and stability of nucleic acid payloads, contributing to advancements in molecular biology and biomedical research.

18:1 Biotinyl Cap PE is a biotinylated phospholipid that incorporates a fluorescent head group, enhancing its utility in liposome research and applications. This reagent is ideal for the preparation of biotinylated liposomes, facilitating studies in targeted drug delivery, membrane dynamics, and cellular uptake. Its unique properties enable researchers to explore interactions at the cellular level and develop innovative strategies for bioconjugation and diagnostics.

18:1 Dodecanyl PE is a phosphoethanolamine lipid that features a carboxylic acid functional group coupled with a twelve-carbon dodecanyl linker and two oleic acid tails. This compound forms stable liposomes, making it valuable for drug delivery and membrane studies. Its amphiphilic properties enhance its applications in the development of lipid-based nanocarriers and membrane model systems in biophysical and biochemical research.

18:1 MPB PE is a maleimide-functionalized lipid designed to facilitate thiol reactions, featuring a phosphoethanolamine head group attached to two oleic acid tails and a phenyl maleimide moiety. This reagent is ideal for the preparation of liposomes and can be used for targeted drug delivery applications and the development of lipid-based nanoparticles. Its ability to covalently conjugate to thiol-containing molecules makes it valuable for studies in bioconjugation and cellular uptake.

Undecyl 6-bromohexanoate is a lipid-based compound that serves as a key component in the formation of liposomes. This reagent is particularly valuable in the preparation of lipid nanoparticles, which are essential for drug delivery and gene therapy applications. Its ability to enhance encapsulation efficiency makes it suitable for various research studies focusing on nanomedicine and targeted therapeutics.

DLPG is a phospholipid characterized by the inclusion of lauric acid at the sn-1 and sn-2 positions, with a phosphate group linked to glycerol. This compound is primarily utilized in the formation of micelles and liposomes, serving as an essential component in the development of artificial membranes. Its ability to facilitate membrane formation makes DLPG valuable in various research applications, including drug delivery and membrane biophysics studies.

(2S)-3-Keto sphinganine (d6:0) hydrochloride is a structural lipid compound designed for liposome formulation. It facilitates the incorporation of hydrophilic agents within the internal aqueous compartment while allowing lipophilic compounds to integrate into the lipid bilayer. This dual capability enhances the efficacy of drug delivery systems, particularly in the realms of cancer therapy and infectious disease treatment. Its application is especially beneficial for the delivery of antisense oligonucleotides, addressing challenges associated with cellular uptake and systemic stability.

DOPE-PEG-Amine (MW 2000) is a phospholipid conjugated to a polydisperse polyethylene glycol (PEG) that serves as a versatile amphiphilic molecule. Its unique structure facilitates the formation of lipid bilayers or micelles in aqueous environments, making it ideal for the preparation of liposomes or nanoparticles. This reagent is particularly useful in targeted drug delivery applications and contains reactive alkyne sites, enabling the formation of triazole rings for bio-conjugation purposes.

SIL lipid is a synthetic ionizable lipid designed for the formation of lipid nanoparticles (LNPs), facilitating efficient siRNA delivery. Its primary mechanism involves enabling the encapsulation and protection of nucleic acids, enhancing cellular uptake and gene silencing potential. This reagent is valuable for researchers focused on RNA-based therapeutics and nanomedicine applications.

LP-371-p is a specialized lipid designed for the efficient delivery of oligonucleotide compounds to adipose tissues, notably fat cells. This reagent plays a significant role in research targeting diseases associated with adiposity, including obesity and type 2 diabetes. Its ability to facilitate targeted delivery of nucleic acids makes it a valuable tool in metabolic disease studies.

Lipid R6 is a lipid compound designed for the synthesis of liposomes and serves as a key component in lipid nanoparticle (LNP) formulations. It plays a critical role in the delivery of nucleic acids and therapeutics, enhancing cellular uptake and bioavailability. Lipid R6 is widely utilized in research applications focused on drug delivery systems and vaccine development.