Liposome

Cyclo(δ-Ala-L-Val) is a cyclic dipeptide that acts as a potential quorum sensing molecule produced by Pseudomonas aeruginosa. This compound is significant in studying bacterial communication and biofilm formation, making it valuable for research in microbiology and infectious disease. Its role in liposome interactions provides further avenues for investigating its effects on drug delivery systems and microbial behavior.

CDC14A/B-IN-1 is a potent inhibitor of CDC14A and CDC14B phosphatases, demonstrating Ki values of 57.4 nM and 90.0 nM, respectively. This compound is specifically designed for oral administration and is valuable for investigating the roles of CDC14 phosphatases in cell cycle regulation and cancer biology. Research applications include studying the impact of CDC14 inhibition on cellular pathways and potential therapeutic uses in cancer treatments.

DOTA Conjugated JM#21 derivative 7 is a CXCR4-targeting peptide conjugated with DOTA, designed for the synthesis of radioligands. When radiolabeled as 177Lu-DOTA, it demonstrates superior targeting of CXCR4-expressing tumors while exhibiting minimal uptake in non-targeted organs, except for the kidneys. This compound is ideal for research applications involving Radionuclide-Drug Conjugates (RDCs), facilitating advancements in targeted radiotherapy.

Orfamide A is a biosurfactant derived from Pseudomonas sp. F6, primarily targeting liposomal structures. This compound demonstrates significant aphidicidal activity, exhibiting a dose-dependent mortality profile with an LC50 value of 34.5 μg/mL. Orfamide A is suitable for research applications in organic agriculture, particularly for the development of biopesticides aimed at controlling aphid populations.

1-Stearoyl-sn-glycerol 3-phosphate sodium is a bioactive phospholipid that modulates key cellular processes including motility, proliferation, invasion, survival, and growth factor production, primarily through its interaction with G protein-coupled receptors (GPCRs). This compound occurs in low concentrations in plasma and is synthesized during the formation of membrane phospholipids from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position, making it valuable for applications in liposome formulation and membrane biology studies.

DOPE (Dioleoylphosphatidylethanolamine) functions as a neutral helper lipid for cationic liposomes, enhancing their performance in gene delivery applications. By interacting with cationic phospholipids, DOPE significantly improves the transfection efficiency of naked siRNA. This reagent is essential for researchers focused on lipid-based drug delivery systems and nucleic acid therapeutics.

DLin-KC2-DMA is useful cationic lipid for siRNA delivery.

SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles.

DOTMA is one of the first cationic lipid used for gene transfection.

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

DPPC is a zwitterionic phosphoglyceride that can be used for the preparation of liposomal monolayers.

1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis of liposomes.

Cholesteryl oleate is a cholesteryl ester.

DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark.

Si5-N14 is a siloxane-based lipid nanoparticle component that enhances vascular repair and exhibits anti-tumor properties. It effectively facilitates CRISPR-Cas9 editing in transgenic GFP mice and demonstrates an ability to knock out Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) in Lewis lung carcinoma models, contributing to tumor suppression. Additionally, Si5-N14 has been shown to deliver Fibroblast Growth Factor-2 (FGF-2) mRNA in models of viral-induced lung injury, promoting vascular repair, increasing blood oxygen levels, and enhancing lung function. This reagent holds significant potential for research applications in oncology, pulmonary disease, and cardiovascular health.

1,3-Diolein is a phospholipid that modulates cell membrane fluidity and facilitates signal transduction. This compound is instrumental in cell biology research, providing insights into lipid-mediated signaling pathways and membrane protein interactions. Additionally, 1,3-Diolein functions as an effective carrier in delivery systems, enhancing the bioavailability of various compounds for improved experimental outcomes.

DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped phospholipid that serves as a critical component in liposome synthesis. This lipid is widely utilized in the formulation of lipid nanoparticles (LNPs) for drug delivery applications. DSPC enhances membrane stability and facilitates the encapsulation of therapeutic agents, making it essential for effective lipid-based drug delivery systems in pharmaceutical research.

DMG-PEG 2000 is a key reagent for the formulation of liposomes, primarily utilized in the delivery of siRNA to enhance transfection efficiency in vitro. Additionally, it serves as a critical component in lipid nanoparticles designed for oral plasmid DNA delivery in vivo, facilitating surface modification that improves mucus permeability and overall delivery efficiency of the nanoparticles.

PEG(2000)-C-DMG is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycerol designed to facilitate the formation of lipid nanoparticles (LNPs). This compound enhances the stability and delivery efficiency of therapeutic agents, particularly siRNA. Its unique properties make it a valuable tool for researchers focused on gene therapy and nucleic acid delivery applications.

Distearoylphosphatidylserine sodium is an anionic phospholipid characterized by its stearic acid tails (18:0) and functional head groups containing both carboxylic acid and amine functionalities. This compound is essential in the preparation of liposomes and lipid-mixing vesicles, serving as a key component in artificial membrane formation. Its medium-length fatty acid chains facilitate the development of thinner lipid membranes, making it valuable for various biochemical applications, including drug delivery and biophysical studies.

1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium primarily functions as a key component in liposome formulations. This phospholipid enhances the stability and encapsulation efficiency of liposomes, facilitating targeted drug delivery. Its use is significant in various biomedical applications, including drug formulation and gene delivery systems.

DOPE-Mal is a synthetic phospholipid analog of phosphatidylethanolamine (PE) featuring 18:1 fatty acids at the sn-1 and sn-2 positions, along with a terminal maleimide group. The reactive maleimide moiety enables covalent bonding with thiol groups, facilitating functionalization in various applications. The inclusion of a hydrophilic PEG spacer enhances its solubility in aqueous environments, making it suitable for liposome formulation and bioconjugation in biochemical research.

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium is an anionic phospholipid featuring two myristic acid (C14:0) tails and a head group that includes both a carboxylic acid and an amine functional group. This compound is primarily utilized in the formulation of liposomes, serving as a crucial component for drug delivery and membrane model studies. Its unique structural properties enable enhanced interaction with cellular membranes, making it valuable for various biomedical and pharmaceutical research applications.

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium is an anionic phospholipid that plays a crucial role in drug delivery systems, particularly in liposome formulation. This compound facilitates the development of liposomes that can selectively induce regulatory T cells (Tregs) responsive to the encapsulated cargo. Additionally, uptake by antigen-presenting cells is mediated through the complement component 1q (C1q), enhancing its potential for targeted therapeutic applications.

244cis is a piperazine-containing ionizable cationic lipid designed for the generation of lipid nanoparticles (LNPs). These LNPs, when complexed with mRNA reporter genes, exhibit a targeted accumulation in mouse lungs, enhancing gene delivery efficiency. Additionally, 244cis is associated with a reduction in serum levels of chemokine (C-C motif) ligand 2 (CCL2), suggesting potential applications in inflammatory response studies and therapeutic interventions.

1,2-Dierucoyl-sn-glycero-3-phosphocholine (DEPC) is a phospholipid that is integral to liposome membrane composition. It is utilized for the preparation of liposomes and provides valuable insights into the properties of lipid bilayers. DEPC-liposomes exhibit enhanced activity, particularly in studies involving glucose oxidase, making it a vital tool for research in cellular delivery systems and membrane dynamics.

C10-200 is an ionizable cationic lipid that primarily targets the generation of lipid nanoparticles (LNPs). It facilitates mRNA delivery, making it a valuable tool for research in gene therapy and RNA-based therapeutics. The compound’s properties enable efficient encapsulation and protection of nucleotides, enhancing cellular uptake and therapeutic efficacy in biological studies.

SPPC is a phospholipid featuring a unique combination of fatty acids, with stearic acid (18:0) at the sn-1 position and palmitic acid (16:0) at the sn-2 position. This structural design enhances its ability to form liposomes, making it valuable for drug delivery systems and membrane studies. SPPC is utilized in research focused on lipid bilayer interactions, vesicle stability, and the formulation of nanocarriers for therapeutic applications.

16:0 DAP is a cationic lipid primarily utilized for the formulation of positively charged liposomes. This compound is effective in facilitating drug delivery, enhancing gene transfection, and providing a platform for vaccine development. Its unique properties allow for improved cellular uptake and payload delivery, making it a valuable reagent in various biomedical research applications.

Boc-Pro-OMe (Boc-L-proline methyl ester) serves as a lipid compound primarily used for liposome formulation. These liposomes consist of concentric phospholipid bilayer membranes and are integral to developing targeted drug delivery systems, particularly in oncology and infectious disease research. Boc-Pro-OMe effectively encapsulates highly polar, water-soluble compounds in the internal aqueous space, while lipophilic agents integrate into the lipid bilayer. This compound is particularly valuable for delivering antisense oligonucleotides, addressing challenges of cellular uptake and stability in biological environments.

1-Stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine is a phospholipid primarily utilized in liposome formulations. This compound facilitates the encapsulation of both hydrophilic and hydrophobic therapeutic agents, making it an essential component in drug delivery systems, particularly in oncology and infectious disease research. Its distinctive properties enable efficient cellular uptake of bioactive molecules, including antisense oligonucleotides, while mitigating degradation in biological environments.

1,2-Dipalmitoyl-sn-glycero-3-phospho-N,N-dimethylethanolamine is a phospholipid that serves as a key component in the formation of liposomes. It is widely utilized in studies related to membrane permeability and the characterization of monolayer viscosity. This compound is essential for researchers investigating lipid bilayer dynamics and the biophysical properties of membranes.

1-Myristoyl-2-hydroxy-sn-glycero-3-PG sodium is a lysophospholipid with myristic acid (14:0) at the sn-1 position, serving as a crucial component in the formation of liposomes and micelles. Its ability to facilitate the assembly of artificial membranes underlines its utility in research involving lipid-based drug delivery systems. This compound supports investigations into membrane biophysics and the development of novel therapeutic carriers.

16:0 Succinyl PE is a carboxylic acid-functionalized lipid that features a two-carbon linker connecting phosphoethanolamine to two palmitic acid tails. This compound is primarily utilized in liposome formulation, providing essential structural integrity and stability. Its unique properties make it suitable for various research applications, including drug delivery systems and membrane biophysics studies.

17:1 Lyso PC is a specialized liposome designed to mimic biological phospholipid membranes. This reagent provides a versatile platform for constructing drug delivery systems, particularly in the fields of oncology and infectious diseases. Its unique structure enables the encapsulation of highly polar, water-soluble molecules within the internal aqueous space, while lipophilic compounds can integrate into the lipid bilayer. Notably, 17:1 Lyso PC is effective for delivering antisense oligonucleotides, addressing challenges related to cellular uptake and metabolic stability.

16:0 Biotinyl PE is a biotinylated phosphoethanolamine lipid that incorporates two palmitic acid moieties, facilitating its use in the formulation of liposomes. This compound serves as a versatile component for biotin-labeling applications, promoting targeting and cellular uptake in various biological studies. Its unique structure allows for the creation of liposomal systems that can deliver therapeutic agents or facilitate cellular imaging and tracking in research contexts.

1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphocholine is an asymmetrical phospholipid characterized by saturated fatty acids, palmitic acid at the sn-1 position and stearic acid at the sn-2 position, with a phosphate group linked to choline. This compound is essential in the formation of liposomes, serving as a critical component in membrane studies and drug delivery systems. Its unique structural properties make it invaluable for researching lipid bilayer dynamics and cellular interactions.

2H-Cho-Arg TFA is a cationic lipid featuring a 2H-cholesterol backbone conjugated to an L-arginine head group. This compound is designed to enhance gene transfection efficiency by interacting with lipid bilayers and facilitating nucleic acid delivery. Its liposomal formulation is particularly valuable in gene therapy and other molecular biology applications, where effective transfection is critical for research and therapeutic purposes.

Heptadecan-9-yl 8-bromooctanoate is a lipid compound primarily used in the construction and modification of liposomes. This reagent plays a crucial role in enhancing the stability and performance of lipid nanoparticles in drug delivery systems. Its unique structure allows for improved interactions with biological membranes, facilitating the effective encapsulation and release of therapeutic agents in various research applications.

1,3-Dipalmitoyl-glycero-2-phosphoethanolamine is a phospholipid featuring saturated long-chain palmitic acid at the sn-1 and sn-3 positions, with phosphoethanolamine at the sn-2 position. This compound is essential for the formation of liposomes and micelles, making it a valuable reagent for studies in membrane biophysics and drug delivery applications. Its structural properties enable the creation of artificial membranes, facilitating the exploration of lipid interactions and membrane dynamics in biological research.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate is a phospholipid characterized by the presence of saturated palmitic acid at the sn-1 position and monounsaturated oleic acid at the sn-2 position. This compound is pivotal in the formation of liposomes, micelles, and various artificial membrane systems. Its biological activity supports applications in drug delivery, membrane biophysics, and the study of membrane interactions in cellular processes.

9-Amino-NeuAc is an amino derivative of neuraminic acid that serves as a substrate for neuraminic acid synthase. This compound can be converted to CMP-9-amino-NeuAc, which acts as an activated CMP-glycoside for transfer to asialoglycoproteins. 9-Amino-NeuAc is valuable in liposome synthesis applications and has the potential to enhance tumor surface immunogenicity, making it useful for research in cancer immunotherapy and targeted drug delivery systems.

RCB-02-4-8 is an ionizable cationic lipid designed for the formation of lipid nanoparticles (LNPs) for mRNA delivery. It enhances the efficiency of lung transfection in murine models, making it a valuable tool for studies in gene therapy and vaccine development. Its application in LNP formulations facilitates targeted delivery of nucleotides, contributing to advancements in molecular biology and therapeutic research.

2-Arachidonoyl-sn-glycero-3-phosphocholine is a phospholipid that primarily functions as a key component of cell membranes. It plays a critical role in regulating membrane fluidity and facilitating signal transduction as well as cell-cell communication. This compound is particularly relevant in research related to inflammatory responses and the study of liposomes for drug delivery and membrane biophysics.

L202 is an ionizable cationic lipid with a pKa of 6.04, designed for the formulation of liposomes. This reagent facilitates the incorporation of mRNA and lipid nanoparticles, making it instrumental in the study of gene delivery and RNA therapeutics. Its unique properties enhance the stability and efficacy of lipid-based delivery systems, thus broadening research applications in mRNA-based therapeutics and nanomedicine.

Biotin-PEGn-NHS ester is a biotinylated linker that facilitates the synthesis of PROTAC molecules by targeting liposomal delivery systems. This compound demonstrates the ability to bind with free neutral avidin, enhancing the specificity for malignant glioma cells. Additionally, Biotin-PEGn-NHS ester can be conjugated to amino groups in GelMA to create biotin-modified functionalized hydrogels, such as gelatin methacryloyl (Bio-GelMA), enabling advanced applications in tissue engineering and drug delivery.

C13-112-tri-tail is a cationic lipid-like compound that features a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. This unique composition enables the formulation of lipid nanoparticles (LNPs), which are essential for applications in drug delivery and gene therapy. C13-112-tri-tail serves as an effective component in enhancing cellular uptake and improving the stability of therapeutic payloads in various biochemical and biomedical research settings.

6-(3-Hydroxypropylamino)hexyl 2-hexyldecanoate is an ionizable lipid primarily utilized in the formation of liposomes. This compound features an ester bond near the sixth carbon relative to the amine nitrogen, which may enhance liver clearance. Its properties make it valuable in mRNA delivery systems and other applications in nanomedicine and drug formulation.

C13-113-tetra-tail is a cationic lipid-like compound that features a polar amino alcohol head group connected to four hydrophobic carbon-13 tails via a tertiary amine linker. This structure enables efficient formulation into lipid nanoparticles (LNPs), facilitating cellular delivery of nucleic acids and other therapeutic agents. Its properties make C13-113-tetra-tail a valuable tool for research applications in drug delivery and gene therapy.

19:0 PC is a saturated phospholipid primarily used as a standard for quantifying phosphatidylcholines in human synovial fluid. This compound facilitates the study of lipid bilayer phase transition dynamics, providing insights into membrane behavior and stability. Its role in liposome formulation further enhances its applications in membrane biology and drug delivery research.