244cis is a piperazine-containing ionizable cationic lipid designed for the generation of lipid nanoparticles (LNPs). These LNPs, when complexed with mRNA reporter genes, exhibit a targeted accumulation in mouse lungs, enhancing gene delivery efficiency. Additionally, 244cis is associated with a reduction in serum levels of chemokine (C-C motif) ligand 2 (CCL2), suggesting potential applications in inflammatory response studies and therapeutic interventions.
244cis is a piperazine-containing ionizable cationic lipid designed for the generation of lipid nanoparticles (LNPs). These LNPs, when complexed with mRNA reporter genes, exhibit a targeted accumulation in mouse lungs, enhancing gene delivery efficiency. Additionally, 244cis is associated with a reduction in serum levels of chemokine (C-C motif) ligand 2 (CCL2), suggesting potential applications in inflammatory response studies and therapeutic interventions.
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