Lisavanbulin dihydrochloride is a microtubule inhibitor that functions as a prodrug for the active compound Avanbulin. It demonstrates significant antitumor activity, particularly in tumors with elevated levels of end-binding protein 1, by targeting tumor cell proliferation and modulating the tumor microenvironment through the reduction of tumor microvasculature. Additionally, Lisavanbulin dihydrochloride activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or aberrant chromosome segregation. This compound is relevant for research focused on diffuse large B cell lymphoma (DLBCL) and glioblastoma.
Lisavanbulin dihydrochloride is a microtubule inhibitor that functions as a prodrug for the active compound Avanbulin. It demonstrates significant antitumor activity, particularly in tumors with elevated levels of end-binding protein 1, by targeting tumor cell proliferation and modulating the tumor microenvironment through the reduction of tumor microvasculature. Additionally, Lisavanbulin dihydrochloride activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or aberrant chromosome segregation. This compound is relevant for research focused on diffuse large B cell lymphoma (DLBCL) and glioblastoma.
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