Lisavanbulin is a prodrug of the microtubule-targeting agent Avanbulin, functioning as an effective antitumor agent with the ability to penetrate the blood-brain barrier. It primarily targets tumor cell proliferation and modifies the tumor microenvironment by reducing tumor microvasculature. Additionally, Lisavanbulin activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or abnormal chromosome segregation. This reagent is relevant for research applications in diffuse large B cell lymphoma (DLBCL) and glioblastoma.
Lisavanbulin is a prodrug of the microtubule-targeting agent Avanbulin, functioning as an effective antitumor agent with the ability to penetrate the blood-brain barrier. It primarily targets tumor cell proliferation and modifies the tumor microenvironment by reducing tumor microvasculature. Additionally, Lisavanbulin activates the spindle assembly checkpoint, leading to cell cycle arrest, cell death, or abnormal chromosome segregation. This reagent is relevant for research applications in diffuse large B cell lymphoma (DLBCL) and glioblastoma.
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