Lithocholic acid 3-sulfate (disodium) is a GPR39 agonist demonstrating robust activation with EC50 values of 0.88 μM in the presence of Zn2+ and 41 μM in its absence, in relevant cell lines. This compound initiates intracellular calcium signaling through GPR39, not relying on Zn2+-binding sites. Additionally, it functions as a ligand for RORγt, selectively inhibiting Th17 cell differentiation. Lithocholic acid 3-sulfate (disodium) is valuable for investigations into cholestatic liver diseases and related immunological studies.
Lithocholic acid 3-sulfate (disodium) is a GPR39 agonist demonstrating robust activation with EC50 values of 0.88 μM in the presence of Zn2+ and 41 μM in its absence, in relevant cell lines. This compound initiates intracellular calcium signaling through GPR39, not relying on Zn2+-binding sites. Additionally, it functions as a ligand for RORγt, selectively inhibiting Th17 cell differentiation. Lithocholic acid 3-sulfate (disodium) is valuable for investigations into cholestatic liver diseases and related immunological studies.
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