LJ-2698 is an orally active antagonist of the adenosine A3 receptor. This compound demonstrates significant anti-inflammatory effects by increasing levels of anti-inflammatory cytokines and promoting the proliferation of M2 macrophages in lung tissues, leading to improved pulmonary function and reduced alveolar cavity enlargement. Additionally, LJ-2698 has shown potential in preventing renal injury associated with diabetic nephropathy by inhibiting lipid accumulation and enhancing PGC1α expression in renal tissues. This reagent is suitable for research applications related to emphysema and diabetic nephropathy.
LJ-2698 is an orally active antagonist of the adenosine A3 receptor. This compound demonstrates significant anti-inflammatory effects by increasing levels of anti-inflammatory cytokines and promoting the proliferation of M2 macrophages in lung tissues, leading to improved pulmonary function and reduced alveolar cavity enlargement. Additionally, LJ-2698 has shown potential in preventing renal injury associated with diabetic nephropathy by inhibiting lipid accumulation and enhancing PGC1α expression in renal tissues. This reagent is suitable for research applications related to emphysema and diabetic nephropathy.
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