LJ-4517 is a highly selective antagonist of the adenosine A2A receptor (A2AAR) with a binding affinity (Ki) of 18.3 nM. This compound effectively displaces the binding of [3H]ZM241385 at wild-type A2AAR, demonstrating its potency in modulating adenosine signaling pathways. Additionally, LJ-4517 features an alkyne moiety, enabling its use as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) applications. This dual functionality makes it a valuable tool for diverse biochemical research.
LJ-4517 is a highly selective antagonist of the adenosine A2A receptor (A2AAR) with a binding affinity (Ki) of 18.3 nM. This compound effectively displaces the binding of [3H]ZM241385 at wild-type A2AAR, demonstrating its potency in modulating adenosine signaling pathways. Additionally, LJ-4517 features an alkyne moiety, enabling its use as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) applications. This dual functionality makes it a valuable tool for diverse biochemical research.
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