LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). This compound facilitates the activation of downstream signaling pathways, notably enhancing the production of cyclic adenosine monophosphate (cAMP) and stimulating the cAMP response element-binding protein (CREB) pathway. LNS8801 demonstrates anti-tumor properties, including the inhibition of tumor cell proliferation, induction of cell differentiation, and enhancement of tumor immunogenicity. Its research applications are relevant across various cancer types, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as investigations into the physiological and pathological roles of GPER.
LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). This compound facilitates the activation of downstream signaling pathways, notably enhancing the production of cyclic adenosine monophosphate (cAMP) and stimulating the cAMP response element-binding protein (CREB) pathway. LNS8801 demonstrates anti-tumor properties, including the inhibition of tumor cell proliferation, induction of cell differentiation, and enhancement of tumor immunogenicity. Its research applications are relevant across various cancer types, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as investigations into the physiological and pathological roles of GPER.
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