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- Stella Liong, .et al. Placental Ras Regulates Inflammation Associated with Maternal Obesity, Mediators Inflamm, 2018, 2018: 3645386 PMID: 30402038
Biological Activity
Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.
Targets
| H-ras (Cell-free assay) | N-ras (Cell-free assay) | K-ras-4B (Cell-free assay) | ||
| 1.9 nM | 2.8 nM | 5.2 nM |
| In vitro | DMSO | 116 mg/mL (181.58 mM) | |
| Water | Insoluble | ||
| Ethanol | 116 mg/mL (181.58 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.65 mL | 78.27 mL | 156.54 mL |
| 0.5 mM | 3.13 mL | 15.65 mL | 31.31 mL |
| 1 mM | 1.57 mL | 7.83 mL | 15.65 mL |
| 5 mM | 0.31 mL | 1.57 mL | 3.13 mL |
*The above data is based on the productmolecular weight 638.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12328 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 193275-84-2 |
| Formula | C27H31Br2ClN4O2 |
| M. Wt | 638.82 |
| Purity | >98% |
| Synonyms | Sarasar, SCH 66336, SCH66336, SCH-66336 |
| SMILES | C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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