Lopinavir-d7 is a deuterated derivative of Lopinavir, a selective peptidomimetic inhibitor targeting the HIV-1 protease. It demonstrates potent activity, with Ki values ranging from 1.3 to 3.6 pM against both wild-type and mutant HIV proteases, effectively preventing HIV-1 maturation and subsequent infectivity. Additionally, Lopinavir has been identified as an inhibitor of SARS-CoV 3CLpro, showcasing an IC50 of 14.2 μM, making it valuable for research in virology and antiviral drug development.
Lopinavir-d7 is a deuterated derivative of Lopinavir, a selective peptidomimetic inhibitor targeting the HIV-1 protease. It demonstrates potent activity, with Ki values ranging from 1.3 to 3.6 pM against both wild-type and mutant HIV proteases, effectively preventing HIV-1 maturation and subsequent infectivity. Additionally, Lopinavir has been identified as an inhibitor of SARS-CoV 3CLpro, showcasing an IC50 of 14.2 μM, making it valuable for research in virology and antiviral drug development.
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