Lorotomidate is a GABAA receptor agonist known for its anesthetic properties, exhibiting an ED50 of 2 mg/kg intravenously in KM mice, while demonstrating an LD50 of 46.5 mg/kg in the same model. This compound’s unique profile includes the ability to maintain corticosteroid secretion, which highlights its safety and efficacy. Lorotomidate is utilized in research to explore anesthetic mechanisms and neuro pharmacology, contributing to studies aimed at understanding GABAA receptor modulation.
Lorotomidate is a GABAA receptor agonist known for its anesthetic properties, exhibiting an ED50 of 2 mg/kg intravenously in KM mice, while demonstrating an LD50 of 46.5 mg/kg in the same model. This compound’s unique profile includes the ability to maintain corticosteroid secretion, which highlights its safety and efficacy. Lorotomidate is utilized in research to explore anesthetic mechanisms and neuro pharmacology, contributing to studies aimed at understanding GABAA receptor modulation.
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