LSD1-IN-34 is a potent inhibitor of Lysine-specific demethylase 1 (LSD1) and monoamine oxidase A (MAO). It demonstrates IC50 values of 4.51 nM for LSD1 and 18.46 nM for MAO A, effectively blocking the activation of neonatal rat myocardial fibroblasts (NRCFs) induced by Ang II, with minimal toxicity at 20 μM. Furthermore, LSD1-IN-34 disrupts the TGFβ/Smad signaling pathway, providing therapeutic potential in ameliorating heart failure in mouse models. The compound also shows favorable pharmacokinetic properties in rats, supporting its use in cardiovascular research.
LSD1-IN-34 is a potent inhibitor of Lysine-specific demethylase 1 (LSD1) and monoamine oxidase A (MAO). It demonstrates IC50 values of 4.51 nM for LSD1 and 18.46 nM for MAO A, effectively blocking the activation of neonatal rat myocardial fibroblasts (NRCFs) induced by Ang II, with minimal toxicity at 20 μM. Furthermore, LSD1-IN-34 disrupts the TGFβ/Smad signaling pathway, providing therapeutic potential in ameliorating heart failure in mouse models. The compound also shows favorable pharmacokinetic properties in rats, supporting its use in cardiovascular research.
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