Lumateperone-d4 is a deuterium-labeled analog of Lumateperone, primarily targeting the 5-HT2A receptor as an antagonist (Ki = 0.54 nM). It exhibits dual action as a partial agonist at presynaptic D2 receptors and an antagonist at postsynaptic D2 receptors (Ki = 32 nM), along with modulation of dopamine D1 receptors. This compound is valuable for investigating schizophrenia, bipolar depression, and has demonstrated anticancer properties, making it a versatile tool in chemical research.
Lumateperone-d4 is a deuterium-labeled analog of Lumateperone, primarily targeting the 5-HT2A receptor as an antagonist (Ki = 0.54 nM). It exhibits dual action as a partial agonist at presynaptic D2 receptors and an antagonist at postsynaptic D2 receptors (Ki = 32 nM), along with modulation of dopamine D1 receptors. This compound is valuable for investigating schizophrenia, bipolar depression, and has demonstrated anticancer properties, making it a versatile tool in chemical research.
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