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Lurbinectedin (PM01183) is a new DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.74 mL | 63.7 mL | 127.41 mL |
| 0.5 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 1 mM | 1.27 mL | 6.37 mL | 12.74 mL |
| 5 mM | 0.25 mL | 1.27 mL | 2.55 mL |
*The above data is based on the productmolecular weight 784.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18237 |
|---|---|
| CAS No. | 497871-47-3 |
| Formula | C41H44N4O10S |
| M. Wt | 784.88 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | Lurbinectedin; PM01183; PM-01183; UNII-2CN60TN6ZS |
| SMILES | Cc1cc2c(c(c1OC)O)[[email protected]@H]3[[email protected]@H]4[[email protected]]5c6c(c7c(c(c6OC(=O)C)C)OCO7)[[email protected]@H](N4[[email protected]]([[email protected]](C2)N3C)O)COC(=O)[[email protected]@]8(CS5)c9c(c1cc(ccc1[nH]9)OC)CCN8 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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