Lurosetron is a potent 5-HT3 receptor antagonist, specifically developed as a 6-fluoro analogue of Alosetron. This compound demonstrates significant biological activity through the inhibition of recombinant cytochrome P450 isoforms, including rbtCYP1A2 with an IC50 of 0.1 μM, as well as rbtCYP2C9 and rbtCYP3A4, exhibiting IC50 values ranging from 3.5 μM to 16 μM. Lurosetron is primarily utilized in research focused on gastrointestinal disorders and the modulation of serotonin pathways.
Lurosetron is a potent 5-HT3 receptor antagonist, specifically developed as a 6-fluoro analogue of Alosetron. This compound demonstrates significant biological activity through the inhibition of recombinant cytochrome P450 isoforms, including rbtCYP1A2 with an IC50 of 0.1 μM, as well as rbtCYP2C9 and rbtCYP3A4, exhibiting IC50 values ranging from 3.5 μM to 16 μM. Lurosetron is primarily utilized in research focused on gastrointestinal disorders and the modulation of serotonin pathways.
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