Luvadaxistat is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO), demonstrating an IC50 value of 14 nM in the inhibition of oxidative deamination of D-serine. This compound significantly elevates D-serine concentrations in various biological matrices, including the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat holds promise as a valuable tool for research into schizophrenia and related neurobiological disorders.
Luvadaxistat is a highly selective and potent inhibitor of D-amino acid oxidase (DAAO), demonstrating an IC50 value of 14 nM in the inhibition of oxidative deamination of D-serine. This compound significantly elevates D-serine concentrations in various biological matrices, including the rodent brain, plasma, and cerebrospinal fluid. Luvadaxistat holds promise as a valuable tool for research into schizophrenia and related neurobiological disorders.
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