LY 3200882

Catalog No.: A16816

TGFβRI inhibitor

LY 3200882

LY 3200882 Chemical Structure

CAS NO. 1898283-02-7

LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.

Availability: In stock

Package Price Qty
2 mg
$60.00
5 mg
$110.00
10 mg
$180.00
50 mg
$580.00
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Biological Activity

LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion.
In vitro DMSO 79 mg/mL (181.39 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.96 mL 114.81 mL 229.61 mL
0.5 mM 4.59 mL 22.96 mL 45.92 mL
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL

*The above data is based on the productmolecular weight 435.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16816
Actions Inhibitor
CAS No. 1898283-02-7
Formula C24H29N5O3
M. Wt 435.52
Purity >98%
Synonyms LY-3200882, LY3200882
SMILES CC(O)(C)C1=NC=CC(NC2=NC=CC(OC3=CN(C4CC4)N=C3C5CCOCC5)=C2)=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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