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LY2228820 (Ralimetinib)

Catalog No.: A10545

p38 MAPK inhibitor

LY2228820 (Ralimetinib)

LY2228820 (Ralimetinib) Chemical Structure

CAS NO. 862507-23-1

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
p38α (Cell-free assay)
7 nM
In vitro (25°C) DMSO Warmed: 4 mg/mL (6.52 mM)
Water Warmed: 91 mg/mL (148.51 mM)
Ethanol 3 mg/mL (4.89 mM)
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.32 mL 81.61 mL 163.21 mL
0.5 mM 3.26 mL 16.32 mL 32.64 mL
1 mM 1.63 mL 8.16 mL 16.32 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 612.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10545
Actions Inhibitor
CAS No. 862507-23-1
Formula C24H29FN6.2CH4O3S
M. Wt 612.7
Purity >98%
Synonyms LY-2228820
SMILES CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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