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Biological Activity
LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.
Targets
p38α (Cell-free assay) | ||||
7 nM |
In vitro (25°C) | DMSO | Warmed: 4 mg/mL (6.52 mM) | |
Water | Warmed: 91 mg/mL (148.51 mM) | ||
Ethanol | 3 mg/mL (4.89 mM) | ||
In vivo | Saline | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 16.32 mL | 81.61 mL | 163.21 mL |
0.5 mM | 3.26 mL | 16.32 mL | 32.64 mL |
1 mM | 1.63 mL | 8.16 mL | 16.32 mL |
5 mM | 0.33 mL | 1.63 mL | 3.26 mL |
*The above data is based on the productmolecular weight 612.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10545 |
---|---|
Actions | Inhibitor |
CAS No. | 862507-23-1 |
Formula | C24H29FN6.2CH4O3S |
M. Wt | 612.7 |
Purity | >98% |
Synonyms | LY-2228820 |
SMILES | CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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