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LY2228820 (Ralimetinib)

LY2228820 (Ralimetinib)

Name: LY2228820 (Ralimetinib)
Brand: Adooq Bioscience
SKU: A10545
Rating: 100 (268 reviews)

Catalog No.: A10545

p38 MAPK inhibitor

LY2228820 (Ralimetinib) Chemical Structure

CAS NO. 862507-23-1

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.

Availability: In stock

Package	Price	Qty
5 mg	$90.00
10 mg	$160.00
50 mg	$580.00
100 mg	$950.00
10mM * 1mL in DMSO	$120.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

LY2228820 is a novel and potent p38MAPK inhibitor with potent antiinflammatory activity.

Targets

p38α (Cell-free assay)
7 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 4 mg/mL (6.52 mM)
	Water	Warmed: 91 mg/mL (148.51 mM)
	Ethanol	3 mg/mL (4.89 mM)
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.32 mL	81.61 mL	163.21 mL
0.5 mM	3.26 mL	16.32 mL	32.64 mL
1 mM	1.63 mL	8.16 mL	16.32 mL
5 mM	0.33 mL	1.63 mL	3.26 mL

*The above data is based on the productmolecular weight 612.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10545
Actions	Inhibitor
CAS No.	862507-23-1
Formula	C24H29FN6.2CH4O3S
M. Wt	612.7
Solubility	DMSO
Purity	>98%
Synonyms	LY-2228820
SMILES	CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.