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Biological Activity
LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.03 mL | 105.13 mL | 210.26 mL |
| 0.5 mM | 4.21 mL | 21.03 mL | 42.05 mL |
| 1 mM | 2.1 mL | 10.51 mL | 21.03 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.21 mL |
*The above data is based on the productmolecular weight 475.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12181 |
|---|---|
| Actions | Agonist |
| CAS No. | 1423018-12-5 |
| Formula | C28H29NO4S |
| M. Wt | 475.6 |
| Purity | >98% |
| Synonyms | LY-2922470, LY 2922470 |
| SMILES | COC1=C(N(CC2=CC=C(COC3=CC=C([[email protected]@H](C#CC)CC(O)=O)C=C3)S2)CCC4)C4=CC=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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