Samotolisib (LY3023414)
Catalog No.: A16126
PI3K/mTOR Dual Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Adooq's Samotolisib (LY3023414) has been cited by 1 publications
- Zou Y, .et al. , Biochem Biophys Res Commun, 2017, Aug 19;490(2):385-392 PMID: 28623128
Biological Activity
| Description | Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). | ||
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Product Information
| Catalog Num | A16126 |
|---|---|
| Formula | C23H26N4O3 |
| Molecular Weight | 406.49 |
| CAS Number | 1386874-06-1 |
| SMILES | CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC |
| Synonyms | LY-3023414, LY 3023414 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro | DMSO | 44 mg/mL (108.24 mM) | |
| Water | Insoluble | ||
| Ethanol | 57 mg/mL (140.22 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.6 mL | 123 mL | 246.01 mL |
| 0.5 mM | 4.92 mL | 24.6 mL | 49.2 mL |
| 1 mM | 2.46 mL | 12.3 mL | 24.6 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
