LY3023414

Catalog No.: A16126
PI3K/mTOR Dual Inhibitor
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
Grouped product items
Product Name Price Stock Qty
LY3023414 5mg
$75.00
In stock
LY3023414 10mg
$130.00
In stock
LY3023414 50mg
$495.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's LY3023414 has been cited by 1 publications
  • Zou Y, .et al. , Biochem Biophys Res Commun, 2017, Aug 19;490(2):385-392 PMID: 28623128
  • Biological Activity
    Discription LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242).
    Targets
    Target Value
    Product Information
    Catalog Num A16126
    Formula C23H26N4O3
    Molecular Weight 406.49
    CAS Number 1386874-06-1
    SMILES CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC
    Synonyms LY-3023414, LY 3023414
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 44 mg/mL (108.24 mM)
    Water Insoluble
    Ethanol 57 mg/mL (140.22 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.6 mL 123 mL 246.01 mL
    0.5 mM 4.92 mL 24.6 mL 49.2 mL
    1 mM 2.46 mL 12.3 mL 24.6 mL
    5 mM 0.49 mL 2.46 mL 4.92 mL
    Useful Calculator

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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