LY364947

Catalog No.: A13446

TGFβR-I Inhibitor

LY364947

LY364947 Chemical Structure

CAS NO. 396129-53-6

LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
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Biological Activity

LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).
Targets
TGFβRI (Cell-free assay) RIPK2 (Cell-free assay) CK1δ (Cell-free assay) TGFβRII (Cell-free assay) MLK-7K (Cell-free assay)
59 nM0.11 μM0.22 μM0.4 μM1.4 μM
In vitro (25°C) DMSO 1 mg/mL (3.67 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 0.71 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.72 mL 183.62 mL 367.24 mL
0.5 mM 7.34 mL 36.72 mL 73.45 mL
1 mM 3.67 mL 18.36 mL 36.72 mL
5 mM 0.73 mL 3.67 mL 7.34 mL

*The above data is based on the productmolecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13446
Actions Inhibitor
CAS No. 396129-53-6
Formula C17H12N4
M. Wt 272.3
Purity >98%
Synonyms HTS 466284 ,TGF-β RI Kinase Inhibitor
SMILES C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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