LY364947

Catalog No.: A13446

TGFβR-I Inhibitor

LY364947 Chemical Structure

CAS NO. 396129-53-6

LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$120.00
50 mg
$200.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

LY364947 is a diheteroaryl-substituted pyrazole compound used as a selective, ATP-competitive inhibitor of TGF-βRI (TGF-β Receptor I kinase).
Targets
TGFβRI (Cell-free assay) RIPK2 (Cell-free assay) CK1δ (Cell-free assay) TGFβRII (Cell-free assay) MLK-7K (Cell-free assay)
59 nM0.11 μM0.22 μM0.4 μM1.4 μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.72 mL 183.62 mL 367.24 mL
0.5 mM 7.34 mL 36.72 mL 73.45 mL
1 mM 3.67 mL 18.36 mL 36.72 mL
5 mM 0.73 mL 3.67 mL 7.34 mL

*The above data is based on the productmolecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13446
Actions Inhibitor
M. Wt 272.3
Formula C17H12N4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 396129-53-6
Synonyms HTS 466284 ,TGF-β RI Kinase Inhibitor
SMILES C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4

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