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$0.00 Biological Activity
LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.
| In vitro | DMSO | 49 mg/mL (74.52 mM) | |
| Water | 98 mg/mL (149.04 mM) | ||
| Ethanol | 98 mg/mL (149.04 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.21 mL | 76.04 mL | 152.08 mL |
| 0.5 mM | 3.04 mL | 15.21 mL | 30.42 mL |
| 1 mM | 1.52 mL | 7.6 mL | 15.21 mL |
| 5 mM | 0.3 mL | 1.52 mL | 3.04 mL |
*The above data is based on the productmolecular weight 657.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16848 |
|---|---|
| Actions | Agonist |
| CAS No. | 2088939-99-3 |
| Formula | C33H45Cl4N3O2 |
| M. Wt | 657.54 |
| Purity | >98% |
| Synonyms | LYN 1604, LYN1604 |
| SMILES | CC(C)CN(CC(N1CCN(CC(C2=CC=C(Cl)C=C2Cl)OCC3=CC=C4C=CC=CC4=C3)CC1)=O)CC(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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