LYN-1604

Catalog No.: A16848

ULK1 agonist

LYN-1604

LYN-1604 Chemical Structure

CAS NO. 2088939-99-3

LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.

Availability: In stock

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5 mg

Regular Price: $140.00

Special Price $112.00

10 mg

Regular Price: $260.00

Special Price $208.00

50 mg

Regular Price: $720.00

Special Price $576.00

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Biological Activity

LYN-1604 is a potential ULK1 agonist with IC50 of 1.66 μM against MDA-MB-231 cells and it binds to wild-type ULK1 with a binding affinity in the nanomole range (Kd=291.4 nM). The ULK1 (Y89A) mutant protein caused a sharp decrease in binding affinity with lower response and Kd than wild-type ULK1, ULK1 (K50A) and ULK1 (L53A) mutants.
In vitro DMSO 49 mg/mL (74.52 mM)
Water 98 mg/mL (149.04 mM)
Ethanol 98 mg/mL (149.04 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.21 mL 76.04 mL 152.08 mL
0.5 mM 3.04 mL 15.21 mL 30.42 mL
1 mM 1.52 mL 7.6 mL 15.21 mL
5 mM 0.3 mL 1.52 mL 3.04 mL

*The above data is based on the productmolecular weight 657.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16848
Actions Agonist
CAS No. 2088939-99-3
Formula C33H45Cl4N3O2
M. Wt 657.54
Purity >98%
Synonyms LYN 1604, LYN1604
SMILES CC(C)CN(CC(N1CCN(CC(C2=CC=C(Cl)C=C2Cl)OCC3=CC=C4C=CC=CC4=C3)CC1)=O)CC(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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