LZ-007 is a highly selective agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 51 nM in TR-FRET assays and 76 nM in HepG2 cells. This compound demonstrates favorable pharmacokinetic properties in SD rats. LZ-007 has shown efficacy in ameliorating metabolic dysfunction associated with steatohepatitis in models of western diet and CCl4-induced mice, making it a valuable tool for research in metabolic diseases and liver dysfunction.
LZ-007 is a highly selective agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 51 nM in TR-FRET assays and 76 nM in HepG2 cells. This compound demonstrates favorable pharmacokinetic properties in SD rats. LZ-007 has shown efficacy in ameliorating metabolic dysfunction associated with steatohepatitis in models of western diet and CCl4-induced mice, making it a valuable tool for research in metabolic diseases and liver dysfunction.
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