Fig. 1 · Structure
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m-PEG13-NHS ester
PROTAC Linkers
m-PEG13-NHS ester is a polyethylene glycol (PEG) derivative designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This reactive NHS ester enables the efficient conjugation of target ligands to E3 ligase moieties, facilitating the assembly of bifunctional molecules that promote targeted protein degradation. Its application enhances the development of novel therapeutic agents in drug discovery and functional proteomics research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3063847-98-0 |
| Applications | PROTAC Linkers |
| Formula | C32H59NO17 |
| Molecular Weight | 729.81 |
| SMILES | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.