m-PEG7-azide serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning through its azide group. This reagent is effective in click chemistry, specifically participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds. This makes m-PEG7-azide a valuable tool for advancing targeted protein degradation research.
m-PEG7-azide serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning through its azide group. This reagent is effective in click chemistry, specifically participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) functionalized compounds. This makes m-PEG7-azide a valuable tool for advancing targeted protein degradation research.
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