Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker that targets thiol groups through its maleimide component, enabling selective labeling of cysteine residues in proteins. This linker incorporates an 8-unit polyethylene glycol (PEG) spacer for improved solubility and a Val-Cit dipeptide that is susceptible to cleavage by cytoplasmic peptidases, facilitating controlled drug release. The PAB and PNP carbonate groups enhance the linker’s reactivity, making it suitable for developing potent and targeted therapeutic agents in cancer research and other applications involving ADCs.
Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker that targets thiol groups through its maleimide component, enabling selective labeling of cysteine residues in proteins. This linker incorporates an 8-unit polyethylene glycol (PEG) spacer for improved solubility and a Val-Cit dipeptide that is susceptible to cleavage by cytoplasmic peptidases, facilitating controlled drug release. The PAB and PNP carbonate groups enhance the linker’s reactivity, making it suitable for developing potent and targeted therapeutic agents in cancer research and other applications involving ADCs.
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