Mal-PEG4-Glu(TFP ester)-NH-m-PEG24

Catalog No.: A84165
PROTAC Linkers
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its application is crucial in the development of therapeutics aimed at modulating protein levels and function in various biological pathways.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its application is crucial in the development of therapeutics aimed at modulating protein levels and function in various biological pathways.
Product Information
Catalog NumA84165
FormulaC78H134F4N4O35
Molecular Weight1763.90
CAS Number2408741-87-5
SMILESO=C(C(NC(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)CCC(OC2=C(F)C(F)=CC(F)=C2F)=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
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