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- Noriaki Ikemura,, .et al. Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine, Chem -Biol Interact, 2019, 306:1-9
Biological Activity
Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.
Targets
| Calcium channel | ||||
| 2.6 nM |
| In vitro (25°C) | DMSO | 19 mg/mL (27.79 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 1 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.63 mL | 73.14 mL | 146.28 mL |
| 0.5 mM | 2.93 mL | 14.63 mL | 29.26 mL |
| 1 mM | 1.46 mL | 7.31 mL | 14.63 mL |
| 5 mM | 0.29 mL | 1.46 mL | 2.93 mL |
*The above data is based on the productmolecular weight 683.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10554 |
|---|---|
| CAS No. | 89226-75-5 |
| Formula | C35H40Cl2N4O6 |
| M. Wt | 683.6 |
| Purity | >98% |
| Synonyms | CV-4093 |
| SMILES | CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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