MAO-B-IN-33 is a potent, reversible, and selective inhibitor of monoamine oxidase-B (MAO-B) with an IC50 of 0.021 μM for MAO-B and 26.805 μM for MAO-A, highlighting its selectivity. Its distinctive action is attributed to steric hindrance caused by differences in amino acid residues between MAO-A and MAO-B. This compound effectively inhibits cerebral MAO-B activity and demonstrates the ability to mitigate MPTP-induced dopaminergic neuronal loss in murine models. MAO-B-IN-33 shows promise for applications in Parkinson's disease research.
MAO-B-IN-33 is a potent, reversible, and selective inhibitor of monoamine oxidase-B (MAO-B) with an IC50 of 0.021 μM for MAO-B and 26.805 μM for MAO-A, highlighting its selectivity. Its distinctive action is attributed to steric hindrance caused by differences in amino acid residues between MAO-A and MAO-B. This compound effectively inhibits cerebral MAO-B activity and demonstrates the ability to mitigate MPTP-induced dopaminergic neuronal loss in murine models. MAO-B-IN-33 shows promise for applications in Parkinson's disease research.
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