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- Roman V Uzhachenko, .et al. Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors, Cell Rep, 2021, Apr 6;35(1):108944 PMID: 33826903
- Karampoor S, .et al. Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis, Int Immunopharmacol, 2020, Mar;80:106138 PMID: 32007705
- Taisuke Ito, .et al. CCR5 is a novel target for the treatment of experimental alopecia areata, JCIA, 2020, 22 January
Biological Activity
Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.
Targets
| MIP-1α (Cell-free assay) | RANTES (Cell-free assay) | MIP-1β (Cell-free assay) | ||
| 3.3 nM | 5.2 nM | 7.2 nM |
| In vitro (25°C) | DMSO | 91 mg/mL (177.15 mM) | |
| Water | Insoluble | ||
| Ethanol | 91 mg/mL (177.15 mM) | ||
| In vivo | 2% DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.47 mL | 97.33 mL | 194.67 mL |
| 0.5 mM | 3.89 mL | 19.47 mL | 38.93 mL |
| 1 mM | 1.95 mL | 9.73 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
*The above data is based on the productmolecular weight 513.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10556 |
|---|---|
| Actions | Antagonist |
| CAS No. | 376348-65-1 |
| Formula | C29H41F2N5O |
| M. Wt | 513.7 |
| Purity | >98% |
| Synonyms | UK-427857, Celsentri |
| SMILES | CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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