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Maraviroc (UK-427857)

Catalog No.: A10556

CCR antagonist

Maraviroc (UK-427857)

Maraviroc (UK-427857) Chemical Structure

CAS NO. 376348-65-1

Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.

Availability: In stock

Package Price Qty
5 mg
25 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Roman V Uzhachenko, .et al. Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors, Cell Rep, 2021, Apr 6;35(1):108944 PMID: 33826903
  • Karampoor S, .et al. Maraviroc attenuates the pathogenesis of experimental autoimmune encephalitis, Int Immunopharmacol, 2020, Mar;80:106138 PMID: 32007705
  • Taisuke Ito, .et al. CCR5 is a novel target for the treatment of experimental alopecia areata, JCIA, 2020, 22 January

Biological Activity

Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.
MIP-1α (Cell-free assay) RANTES (Cell-free assay) MIP-1β (Cell-free assay)
3.3 nM5.2 nM7.2 nM
In vitro (25°C) DMSO 91 mg/mL (177.15 mM)
Water Insoluble
Ethanol 91 mg/mL (177.15 mM)
In vivo 2% DMSO+corn oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.47 mL 97.33 mL 194.67 mL
0.5 mM 3.89 mL 19.47 mL 38.93 mL
1 mM 1.95 mL 9.73 mL 19.47 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10556
Actions Antagonist
CAS No. 376348-65-1
Formula C29H41F2N5O
M. Wt 513.7
Purity >98%
Synonyms UK-427857, Celsentri

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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