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$0.00 - Lv Y, .et al. Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells, ACS Nano, 2018, Feb 27;12(2):1519-1536 PMID: 29350904
- ChaoQin, .et al. Matrix metalloproteinases sensitive multifunctional micelles for inhibition of metastatic tumor growth and metastasis, Powder Technol, 2018, In Press
Biological Activity
Marimastat acted as a broad-spectrum matrix metalloproteinase inhibitor.
Targets
| Target | Value |
|---|---|
| MMP-9 | IC50: 3nM |
| MMP-1 | IC50: 5nM |
| MMP-2 | IC50: 6nM |
| MMP-14 | IC50: 9nM |
| MMP-7 | IC50: 16nM |
| MMP-3 | IC50: 230nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.17 mL | 150.87 mL | 301.74 mL |
| 0.5 mM | 6.03 mL | 30.17 mL | 60.35 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.17 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.03 mL |
*The above data is based on the productmolecular weight 331.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12826 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 331.41 |
| Formula | C15H29N3O5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 154039-60-8 |
| SMILES | CC(C)C[[email protected]]([[email protected]@H](C(=O)NO)O)C(=O)N[[email protected]](C(=O)NC)C(C)(C)C |
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