Catalog No.: A12826

MMP inhibitor


Marimastat Chemical Structure

CAS NO. 154039-60-8

Marimastat acted as a broad-spectrum matrix metalloproteinase inhibitor.

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  • Lv Y, .et al. Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells, ACS Nano, 2018, Feb 27;12(2):1519-1536 PMID: 29350904
  • ChaoQin, .et al. Matrix metalloproteinases sensitive multifunctional micelles for inhibition of metastatic tumor growth and metastasis, Powder Technol, 2018, In Press

Biological Activity

Marimastat acted as a broad-spectrum matrix metalloproteinase inhibitor.
Target Value
MMP-9IC50: 3nM
MMP-1IC50: 5nM
MMP-2IC50: 6nM
MMP-14IC50: 9nM
MMP-7IC50: 16nM
MMP-3IC50: 230nM
In vitro (25°C) DMSO 46 mg/mL (138.8 mM)
Water Insoluble
Ethanol Warmed: 6 mg/mL (18.1 mM)
In vivo 50% DMSO+PBS 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.17 mL 150.87 mL 301.74 mL
0.5 mM 6.03 mL 30.17 mL 60.35 mL
1 mM 3.02 mL 15.09 mL 30.17 mL
5 mM 0.6 mL 3.02 mL 6.03 mL

*The above data is based on the productmolecular weight 331.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12826
Actions Inhibitor
CAS No. 154039-60-8
Formula C15H29N3O5
M. Wt 331.41
Purity >98%
SMILES CC(C)C[[email protected]]([[email protected]@H](C(=O)NO)O)C(=O)N[[email protected]](C(=O)NC)C(C)(C)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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