MDAN-21 is a bivalent ligand that targets the μ-opioid receptor as an agonist and the δ-opioid receptor as an antagonist. This compound exhibits significant analgesic properties, demonstrating effectiveness in reducing pain without the development of tolerance in preclinical mouse models. Additionally, MDAN-21 has shown potential in mitigating morphine withdrawal symptoms in dependent primates and alleviating abnormal pain responses in studies involving rhesus monkeys. It serves as a valuable tool for research on allodynia and pain modulation.
MDAN-21 is a bivalent ligand that targets the μ-opioid receptor as an agonist and the δ-opioid receptor as an antagonist. This compound exhibits significant analgesic properties, demonstrating effectiveness in reducing pain without the development of tolerance in preclinical mouse models. Additionally, MDAN-21 has shown potential in mitigating morphine withdrawal symptoms in dependent primates and alleviating abnormal pain responses in studies involving rhesus monkeys. It serves as a valuable tool for research on allodynia and pain modulation.
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