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- KOLAC UK, .et al. Chemical Inhibition of Mitochondrial Fission Improves Mitochondrial Function and Subdues Hyperglycemia Induced Stress in Placental Trophoblast Cells, Research Square, 2022, 03 Jun
Biological Activity
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.
Targets
| Dynamin1 | ||||
| 1 μM-10 μM |
| In vitro (25°C) | DMSO | 62 mg/mL (175.52 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 6 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.31 mL | 141.55 mL | 283.11 mL |
| 0.5 mM | 5.66 mL | 28.31 mL | 56.62 mL |
| 1 mM | 2.83 mL | 14.16 mL | 28.31 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
*The above data is based on the productmolecular weight 353.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14316 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 338967-87-6 |
| Formula | C15H10Cl2N2O2S |
| M. Wt | 353.22 |
| Purity | >98% |
| Synonyms | Mdivi 1, Mdivi1 |
| SMILES | COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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