Mdivi-1

Catalog No.: A14316

DRP1 inhibitor

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.
Grouped product items
Size Price Stock Qty
5mg
$25.00
In stock
10mg
$45.00
In stock
25mg
$85.00
In stock
50mg
$150.00
In stock
100mg
$230.00
In stock
200mg
$350.00
In stock
500mg
$580.00
In stock
10mM * 1mL in DMSO
$35.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Mdivi-1 has been cited by 2 publications
  • Umut Kerem Kolac, .et al. , Mol Biol Rep, 2023, Jan;50(1):493-506 PMID: 36352179
  • KOLAC UK, .et al. , Research Square, 2022, 03 Jun
  • Biological Activity
    Discription Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 uM.
    Targets
    Target Value
    In Vitro

    In the ganglion cell layer (GCL), Mdivi-1 exhibits strong immunoreactivity. Twelve hours following ischemic induction, Mdivi-1 significantly increases protein expression within the GCL. It notably reduces the expression of GFAP protein without altering Drp1 protein expression. In the normal murine retina, Mdivi-1 primarily localizes to the inner plexiform layer, ganglion cell layer, outer plexiform layer, and inner nuclear layer. Early in the development of the ischemic murine retina, there is a marked increase in the protein expression of Mdivi-1 and glial fibrillary acidic protein (GFAP). Mdivi-1 inhibits apoptosis in the ischemic retina and significantly increases the survival rate of retinal ganglion cells (RGC) two weeks post-ischemia.

    Product Information
    Catalog Num A14316
    Formula C15H10Cl2N2O2S
    Molecular Weight 353.22
    CAS Number 338967-87-6
    SMILES COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
    Synonyms Mdivi 1, Mdivi1
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 62 mg/mL (175.52 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+40% PEG 300+5% Tween 80+ddH2O 6 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 28.31 mL 141.55 mL 283.11 mL
    0.5 mM 5.66 mL 28.31 mL 56.62 mL
    1 mM 2.83 mL 14.16 mL 28.31 mL
    5 mM 0.57 mL 2.83 mL 5.66 mL
    Useful Calculator

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